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KMID : 0960920020010020077
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Dementia and Neurocognitive Disorders
2002 Volume.1 No. 2 p.77 ~ p.82
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Dementia with Parkinsonism: Progressive Supranuclear Palsy
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Lee Jae-Hong
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Abstract
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This article reviews recent advances in the study of progressive supranuclear palsy(PSP) including the new insights into the pathogenesis. PSP is a tauopathy affecting the specific areas of the basal ganglia and the brain stem. Supranuclear gaze palsy, postural instability and falls, and subcortical dementia are unique for the diagnosis. In early stages when supranuclear opthalmoplegia is not apparent, however, it is often challenging to differentiate PSP from the other degenerative disorders presenting parkinsonism with dementia. Several clinical features that distinguish PSP from non-PSP cases were suggested. On neuropsychological test, patients with PSP typically shows slow mental operation, retrieval type of anmnesia, personality change with apathy or depression, and executive dysfunction. This prominent frontal dysfunction is mainly due to frontostriatal circuit disruption caused by basal ganglionic pathology. The cortical from of progressive supranuclear palsy simulating cortical dementia has been reported in which neocortical neurofibrillary tangles and/or neuropil threads are predominant.
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KEYWORD
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Progressive supranuclear palsy, Tauopathy, Parkinsonism, Subcortical dementia
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